I bought 5 bottles (750mg) at a reduced price of $125. I have more than doubled, actually tripled, the recommended dosage, and gone through all of the bottles, and have not noticed even a slight difference in pain. I have fibromyalgia and arthritis. When I called to question dosage, they said to start by taking one drop for ever 10 lbs of weight. One full dropper is supposed to be approx. 24 drops, which according to their recommendations, I should need only 16 drops at most! They say to increase the dosage until you notice a difference. On the bottle, it recommends taking a full dropper per day. I was taking two full droppers(48 drops)/day and noticed no difference at all. At this point, I doubt if a full bottle/day would make any difference. I was so hopeful that it would work, but have my doubts and guess I'm suspicious of any of them now. I would love to see a list of those tested that did NOT meet the standards. This is the second different product I've tried, to no avail. No one wishes, more than I, that it had worked, but it didn't. I am going to a seminar on Regenerative Medicine which uses stem cells to help with arthritis and joint pain. Curious to see how that works as an alternative to surgery.